β₃ -Adrenoceptor as a potential immuno-suppressor agent in melanoma.

ABSTRACT:

Background and purpose

Stress-related catecholamines have a role in cancer and β-adrenoceptors; specifically, β₂ -adrenoceptors have been identified as new targets in treating melanoma. Recently, β₃ -adrenoceptors have shown a pleiotropic effect on melanoma micro-environment leading to cancer progression. However, the mechanisms by which β₃ -adrenoceptors promote this progression remain poorly understood. Catecholamines affect the immune system by modulating several factors that can alter immune cell sub-population homeostasis. Understanding the mechanisms of cancer immune-tolerance is one of the most intriguing challenges in modern research. This study investigates the potential role of β₃ -adrenoceptors in immune-tolerance regulation.

SUBMITTER: Calvani M 

PROVIDER: S-EPMC6592854 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature