Ontology highlight
ABSTRACT:
SUBMITTER: Clark TA
PROVIDER: S-EPMC6593250 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Clark Travis A TA Chung Jon H JH Kennedy Mark M Hughes Jason D JD Chennagiri Niru N Lieber Daniel S DS Fendler Bernard B Young Lauren L Zhao Mandy M Coyne Michael M Breese Virginia V Young Geneva G Donahue Amy A Pavlick Dean D Tsiros Alyssa A Brennan Timothy T Zhong Shan S Mughal Tariq T Bailey Mark M He Jie J Roels Steven S Frampton Garrett M GM Spoerke Jill M JM Gendreau Steven S Lackner Mark M Schleifman Erica E Peters Eric E Ross Jeffrey S JS Ali Siraj M SM Miller Vincent A VA Gregg Jeffrey P JP Stephens Philip J PJ Welsh Allison A Otto Geoff A GA Lipson Doron D
The Journal of molecular diagnostics : JMD 20180622 5
Genomic profiling of circulating tumor DNA derived from cell-free DNA (cfDNA) in blood can provide a noninvasive method for detecting genomic biomarkers to guide clinical decision making for cancer patients. We developed a hybrid capture-based next-generation sequencing assay for genomic profiling of circulating tumor DNA from blood (FoundationACT). High-sequencing coverage and molecular barcode-based error detection enabled accurate detection of genomic alterations, including short variants (ba ...[more]