Ontology highlight
ABSTRACT:
SUBMITTER: Docta RY
PROVIDER: S-EPMC6593660 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Docta Roslin Y RY Ferronha Tiago T Sanderson Joseph P JP Weissensteiner Thomas T Pope George R GR Bennett Alan D AD Pumphrey Nicholas J NJ Ferjentsik Zoltan Z Quinn Laura L LL Wiedermann Guy E GE Anderson Victoria E VE Saini Manoj M Maroto Miguel M Norry Elliot E Gerry Andrew B AB
Hepatology (Baltimore, Md.) 20190214 5
Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic options. Alpha-fetoprotein (AFP) is often expressed at high levels in HCC and is an established clinical biomarker of the disease. Expression of AFP in nonmalignant liver can occur, particularly in a subset of progenitor cells and during chronic inflammation, at levels typically lower than in HCC. This cancer-specific overexpression indicates that AFP may be a promising target for immunotherapy. We verifie ...[more]