Periodontitis as the risk factor of chronic kidney disease: Mediation analysis.

ABSTRACT:

Aim

To determine sequences and magnitude of causality among periodontitis, diabetes and chronic kidney disease (CKD) by mediation analysis.

Methods

Ten-year-data were retrieved from the Electric Generation Authority of Thailand (EGAT) study. A cohort of 2,635 subjects was identified with no CKD at baseline. The interested outcome was CKD incidence defined as glomerular filtration rate <60 ml/min/1.73 m² . The percentage of proximal sites with clinical attachment loss ≥5 mm was used to represent periodontitis. Mediation analysis with 1,000-replication bootstrapping was applied to two causal diagrams, diagram A (Periodontitis → Diabetes → CKD) and diagram B (Diabetes → Periodontitis → CKD).

Results

The cumulative incidence of CKD was 10.3 cases per 100 person

SUBMITTER: Lertpimonchai A 

PROVIDER: S-EPMC6593715 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature