Ontology highlight
ABSTRACT:
SUBMITTER: Minata M
PROVIDER: S-EPMC6594377 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cell reports 20190201 7
Unresectable glioblastoma (GBM) cells in the invading tumor edge can act as seeds for recurrence. The molecular and phenotypic properties of these cells remain elusive. Here, we report that the invading edge and tumor core have two distinct types of glioma stem-like cells (GSCs) that resemble proneural (PN) and mesenchymal (MES) subtypes, respectively. Upon exposure to ionizing radiation (IR), GSCs, initially enriched for a CD133<sup>+</sup> PN signature, transition to a CD109<sup>+</sup> MES su ...[more]