Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.

ABSTRACT:

Aims

Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. Previous association studies of common genetic variants have had limited success in identifying a genetic basis for this adverse drug reaction. We conducted a multi-site whole-exome sequencing study to investigate whether rare coding variants confer an increased risk of SRM.

Methods and results

SRM 3-5 cases (N = 505) and statin treatment-tolerant controls (N = 2047) were recruited from multiple sites in North America and Europe. SRM 3-5 was defined as symptoms consistent with muscle injury and an elevated creatine phosphokinase level >4 times upper limit of normal without another likely cau

SUBMITTER: Floyd JS 

PROVIDER: S-EPMC6594672 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature