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Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.


ABSTRACT: BACKGROUND:Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects the lungs in 90% of patients, but has a wide range of disease manifestations and outcomes including chronic and progressive courses. Noninvasive biomarkers are needed to assess these outcomes and guide decisions for long term monitoring and treatment. Interferon-gamma (IFN-?)-inducible chemotactic cytokines (chemokines), CXCL9, CXCL10 and CXCL11, show promise in this regard because they have been implicated in the pathogenesis of and reflect the burden of granulomatous inflammation. CXCL11 has been reported to have unique functional properties in modulating adaptive immunity in model systems so our goal was to examine serum levels of CXCL11 in relation to clinical outcomes in a heterogeneous cohort of sarcoidosis subjects. METHODS:CXCL19, CXCL10, and CXCL11 serum levels were measured in sarcoidosis and healthy subjects using ELISA assay. We determined relationships between CXCL11 and standard clinical inflammatory markers, expression of IFN-?-related genes in whole blood, organ involvement, dyspnea scores, and measures of pulmonary function. RESULTS:In a cross-sectional analysis of 104 sarcoidosis subjects, serum CXCL11 was significantly elevated compared to 49 healthy controls (p?

SUBMITTER: Arger NK 

PROVIDER: S-EPMC6594698 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis.

Arger Nicholas K NK   Ho Melissa M   Woodruff Prescott G PG   Koth Laura L LL  

Respiratory medicine 20190417


<h4>Background</h4>Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects the lungs in 90% of patients, but has a wide range of disease manifestations and outcomes including chronic and progressive courses. Noninvasive biomarkers are needed to assess these outcomes and guide decisions for long term monitoring and treatment. Interferon-gamma (IFN-γ)-inducible chemotactic cytokines (chemokines), CXCL9, CXCL10 and CXCL11, show promise in this regard because they have been  ...[more]

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