Ontology highlight
ABSTRACT:
SUBMITTER: Sanderson SM
PROVIDER: S-EPMC6594760 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Sanderson Sydney M SM Mikhael Peter G PG Ramesh Vijyendra V Dai Ziwei Z Locasale Jason W JW
Science advances 20190626 6
Codeletions of gene loci containing tumor suppressors and neighboring metabolic enzymes present an attractive synthetic dependency in cancers. However, the impact that these genetic events have on metabolic processes, which are also dependent on nutrient availability and other environmental factors, is unknown. As a proof of concept, we considered panels of cancer cells with homozygous codeletions in <i>CDKN2a</i> and <i>MTAP</i>, genes respectively encoding the commonly-deleted tumor suppressor ...[more]