Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis.
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ABSTRACT:
SUBMITTER: Zha F
PROVIDER: S-EPMC6594792 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis.
Zha Fangfang F Qu Xiaolu X Tang Bo B Li Ji J Wang Yakun Y Zheng PengXi P Ji Tingting T Zhu Chun C Bai Shoujun S
Aging 20190601 11
Long non-coding RNAs (lncRNAs) play vital roles in diabetic nephropathy (DN). This research aimed to study the potential role and underlying molecular mechanisms of long non-coding RNA MEG3 in DN. We found that MEG3 was upregulated in DN in vivo and in vitro and could enhance cell fibrosis and inflammatory response in DN. MEG3 functioned as an endogenous sponge for miR-181a in mesangial cells (MCs) via direct targeting and in an Ago2-dependent manner. MiR-181a inhibition promoted MC fibrosis and ...[more]
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