Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Casacuberta I
PROVIDER: S-EPMC6594812 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
González-Casacuberta Ingrid I Juárez-Flores Diana-Luz DL Ezquerra Mario M Fucho Raquel R Catalán-García Marc M Guitart-Mampel Mariona M Tobías Ester E García-Ruiz Carmen C Fernández-Checa José Carlos JC Tolosa Eduard E Martí María-José MJ Grau Josep Maria JM Fernández-Santiago Rubén R Cardellach Francesc F Morén Constanza C Garrabou Glòria G
Aging 20190601 11
PRKN encodes an E3-ubiquitin-ligase involved in multiple cell processes including mitochondrial homeostasis and autophagy. Previous studies reported alterations of mitochondrial function in fibroblasts from patients with PRKN mutation-associated Parkinson's disease (PRKN-PD) but have been only conducted in glycolytic conditions, potentially masking mitochondrial alterations. Additionally, autophagy flux studies in this cell model are missing.We analyzed mitochondrial function and autophagy in PR ...[more]