Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC6594970 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kim Dongwon D Chen Ruosi R Sheu Mary M Kim Noori N Kim Sooah S Islam Nasif N Wier Eric M EM Wang Gaofeng G Li Ang A Park Angela A Son Wooyang W Evans Benjamin B Yu Victoria V Prizmic Vicky P VP Oh Eugene E Wang Zixiao Z Yu Jianshi J Huang Weiliang W Archer Nathan K NK Hu Zhiqi Z Clemetson Nashay N Nelson Amanda M AM Chien Anna A Okoye Ginette A GA Miller Lloyd S LS Ghiaur Gabriel G Kang Sewon S Jones Jace W JW Kane Maureen A MA Garza Luis A LA
Nature communications 20190626 1
How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predic ...[more]