Ontology highlight
ABSTRACT:
SUBMITTER: Vargas DA
PROVIDER: S-EPMC6595045 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Vargas Deninson Alejandro DA Prieto Miguel Dario MD Martínez-Valencia Alvaro José AJ Cossio Alexandra A Burgess Karl E V KEV Burchmore Richard J S RJS Gómez María Adelaida MA
Frontiers in pharmacology 20190620
Control of cutaneous leishmaniasis (CL) in the Americas is dependent on chemotherapy with parenteral pentavalent antimonials. High rates of treatment failure urge the search for predictive and prognostic markers of therapeutic responsiveness. In this study, we aimed to identify biomarkers of therapeutic response during treatment with meglumine antimoniate (MA). We conducted untargeted metabolomic profiling of plasma samples from CL patients (n = 39; 25 who cured and 14 who did not cure), obtaine ...[more]