Dataset Information

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [¹⁸F]FDG-PET (PETMETPAT).

ABSTRACT:

Introduction

The implementation of spatial-covariance [¹⁸F]fluorodeoxyglucose positron emission tomography-based disease-related metabolic brain patterns as biomarkers has been hampered by intercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illustrate the impact of these differences on Parkinson's disease-related pattern (PDRP) expression scores.

Methods

Five healthy controls, 5 patients with idiopathic rapid eye movement sleep behavior disorder, and 5 patients with Parkinson's disease were scanned on one positron emission tomography/computed tomography system with multiple image reconstructions. In addition, one Hoffman 3D Brain Phantom was scanned on several positron emission tomography/computed tomography systems using various reconstructions. Effects of image contrast on PDRP scores were also examined.

Results

Human and phantom raw PDRP scores were systematically influenced by scanner and reconstruction effects. PDRP scores correlated inversely to image contrast. A Gaussian spatial filter reduced contrast while decreasing intercenter score differences.

Discussion

Image contrast should be considered in harmonization efforts. A Gaussian filter may reduce noise and intercenter effects without sacrificing sensitivity. Phantom measurements will be important for correcting PDRP score offsets.

SUBMITTER: Kogan RV

PROVIDER: S-EPMC6595051 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [<sup>18</sup>F]FDG-PET (PETMETPAT).

Kogan Rosalie V RV de Jong Bas A BA Renken Remco J RJ Meles Sanne K SK van Snick Paul J H PJH Golla Sandeep S Rijnsdorp Sjoerd S Perani Daniela D Leenders Klaus L KL Boellaard Ronald R

Alzheimer's & dementia (Amsterdam, Netherlands) 20190622

<h4>Introduction</h4>The implementation of spatial-covariance [<sup>18</sup>F]fluorodeoxyglucose positron emission tomography-based disease-related metabolic brain patterns as biomarkers has been hampered by intercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illustrate the impact of these differences on Parkinson's disease-related pattern (PDRP) expression scores.<h4>Methods</h4>Five healthy controls, 5 patients with idiopathic rapid eye movement sleep beha ...[more]

PMID: 31294076

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Dataset Information

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [¹⁸F]FDG-PET (PETMETPAT).

Introduction

Methods

Results

Discussion

Publications

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [<sup>18</sup>F]FDG-PET (PETMETPAT).

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [18F]FDG-PET (PETMETPAT).

Introduction

Methods

Results

Discussion

Publications

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [<sup>18</sup>F]FDG-PET (PETMETPAT).

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [¹⁸F]FDG-PET (PETMETPAT).