Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC6595219 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Li Fei F Jiang Changtao C Krausz Kristopher W KW Li Yunfei Y Albert Istvan I Hao Haiping H Fabre Kristin M KM Mitchell James B JB Patterson Andrew D AD Gonzalez Frank J FJ
Nature communications 20130101
The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase (BSH) activity leading to the accumulation of intestinal tauro-β-muricholic acid (T-β-MCA). T-β-MCA is an farnesoid X receptor (FXR) nuclear receptor antagonist, which is involved in the regulation of bile acid, lipid and glucose metabolism. Its increased levels during tempol treatment inhibit FXR signalling in the intes ...[more]