Ontology highlight
ABSTRACT:
SUBMITTER: Shu S
PROVIDER: S-EPMC6595237 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
iScience 20190604
The significance of intracellular Ap<sub>4</sub>A levels over immune activity of dendritic cells (DCs) has been studied in Nudt2<sup>fl/fl</sup>/CD11c-cre mice. The transgenic mice have been generated by crossing floxed NUDT2 gene mice with DC marker CD11c recombinase (cre) mice. The DCs derived from these mice have higher levels of Ap<sub>4</sub>A (≈30-fold) compared with those derived from Nudt2<sup>+/+</sup> mice. Interestingly, the elevated Ap<sub>4</sub>A in DCs has led them to possess high ...[more]