Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC6595338 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhou Jie J Zhao Wenyi W Wu Jingcheng J Lu Jun J Ding Yongfeng Y Wu Shanshan S Wang Haiyong H Ding Ding D Mo Fan F Zhou Zhan Z Teng Lisong L Chen Shuqing S
BioMed research international 20190613
Neoantigens are optimal tumor-specific targets for T-cell based immunotherapy, especially for patients with "undruggable" mutated driver genes. T-cell immunotherapy can be a "universal" treatment for HLA genotype patients sharing same oncogenic mutations. To identify potential neoantigens for therapy in gastric cancer, 32 gastric cancer patients were enrolled in our study. Whole exome sequencing data from these patients was processed by TSNAD software to detect cancer somatic mutations and predi ...[more]