Ontology highlight
ABSTRACT:
SUBMITTER: Zidar N
PROVIDER: S-EPMC6596384 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zidar Nace N Macut Helena H Tomašič Tihomir T Peterlin Mašič Lucija L Ilaš Janez J Zega Anamarija A Tammela Päivi P Kikelj Danijel D
MedChemComm 20190520 6
Due to the rapid development of antimicrobial resistance, the discovery of new antibacterials is essential in the fight against potentially lethal infections. The DNA gyrase B (GyrB) subunit of bacterial DNA gyrase is an excellent target for the design of antibacterials, as it has been clinically validated by novobiocin. However, there are currently no drugs in clinical use that target GyrB. We prepared a new series of <i>N</i>-phenyl-4,5-dibromopyrrolamides and evaluated them against DNA gyrase ...[more]