Ontology highlight
ABSTRACT:
SUBMITTER: Gunner G
PROVIDER: S-EPMC6596419 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Gunner Georgia G Cheadle Lucas L Johnson Kasey M KM Ayata Pinar P Badimon Ana A Mondo Erica E Nagy M Aurel MA Liu Liwang L Bemiller Shane M SM Kim Ki-Wook KW Lira Sergio A SA Lamb Bruce T BT Tapper Andrew R AR Ransohoff Richard M RM Greenberg Michael E ME Schaefer Anne A Schafer Dorothy P DP
Nature neuroscience 20190617 7
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remain a key open question. Here we show that whisker lesioning, known to dampen cortical activity, induces microglia-mediated synapse elimination. This synapse elimination is dependent on signaling by CX3CR1, the receptor for microglial fractalkine (also known as CXCL1), but ...[more]