Effects of combination drugs on antihypertensive medication adherence in a real-world setting: a Korean Nationwide Study.

ABSTRACT:

Objectives

We tried to clarify, by using representative national data in a real-world setting, whether single-pill combinations (SPCs) of antihypertensives actually improve medication adherence.

Design

A nationwide population-based study.

Setting

We used a 2.2% cohort (n=1 048 061) of the total population (n=46 605 433) that was randomly extracted by National Health Insurance of Korea from 2008 to 2013.

Participants

We included patients (n=116 677) who were prescribed with the same antihypertensive drugs for at least 1 year and divided them into groups of angiotensin II receptor blocker (ARB)-only, calcium channel blocker (CCB)-only, multiple-pill combinations (MPCs) and SPCs of ARB/CCB.

Primary outcome measures

Medication possession ratio (MPR), a frequ

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC6596965 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature