Ontology highlight
ABSTRACT:
SUBMITTER: Anderson SM
PROVIDER: S-EPMC6597122 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
PLoS pathogens 20190617 6
Fatty acids affect a number of physiological processes, in addition to forming the building blocks of membranes and body fat stores. In this study, we uncover a role for the monounsaturated fatty acid oleate in the innate immune response of the nematode Caenorhabditis elegans. From an RNAi screen for regulators of innate immune defense genes, we identified the two stearoyl-coenzyme A desaturases that synthesize oleate in C. elegans. We show that the synthesis of oleate is necessary for the patho ...[more]