Ontology highlight
ABSTRACT:
SUBMITTER: Galvan DL
PROVIDER: S-EPMC6597204 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Galvan Daniel L DL Long Jianyin J Green Nathanael N Chang Benny H BH Lin Jamie S JS Schumacker Paul P Truong Luan D LD Overbeek Paul P Danesh Farhad R FR
The Journal of clinical investigation 20190507 7
Phosphorylation of Dynamin-related protein1 (Drp1) represents an important regulatory mechanism for mitochondrial fission. Here we established the role of Drp1 Serine 600 (S600) phosphorylation on mitochondrial fission in vivo, and assessed the functional consequences of targeted elimination of the Drp1S600 phosphorylation site in progression of diabetic nephropathy (DN). We generated a knockin mouse in which S600 was mutated to alanine (Drp1S600A). We found that diabetic Drp1S600A mice exhibite ...[more]