Ontology highlight
ABSTRACT:
SUBMITTER: Guajardo R
PROVIDER: S-EPMC6597256 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Guajardo Ricardo R Luginbuhl David J DJ Han Shuo S Luo Liqun L Li Jiefu J
eLife 20190621
Plexins exhibit multitudinous, evolutionarily conserved functions in neural development. How Plexins employ their diverse structural motifs in vivo to perform distinct roles is unclear. We previously reported that Plexin B (PlexB) controls multiple steps during the assembly of the <i>Drosophila</i> olfactory circuit (Li et al., 2018b). Here, we systematically mutagenized structural motifs of PlexB and examined the function of these variants in these multiple steps: axon fasciculation, trajectory ...[more]