Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Arenas A
PROVIDER: S-EPMC6597577 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Álvarez-Arenas Arturo A Podolski-Renic Ana A Belmonte-Beitia Juan J Pesic Milica M Calvo Gabriel F GF
Scientific reports 20190627 1
Development of drug resistance in cancer has major implications for patients' outcome. It is related to processes involved in the decrease of drug efficacy, which are strongly influenced by intratumor heterogeneity and changes in the microenvironment. Heterogeneity arises, to a large extent, from genetic mutations analogously to Darwinian evolution, when selection of tumor cells results from the adaptation to the microenvironment, but could also emerge as a consequence of epigenetic mutations dr ...[more]