Ontology highlight
ABSTRACT:
SUBMITTER: Levine KM
PROVIDER: S-EPMC6597581 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Levine Kevin M KM Priedigkeit Nolan N Basudan Ahmed A Tasdemir Nilgun N Sikora Matthew J MJ Sokol Ethan S ES Hartmaier Ryan J RJ Ding Kai K Ahmad Nedah Z NZ Watters Rebecca J RJ Weiss Kurt R KR Blohmer Jens-Uwe JU Denkert Carsten C Machleidt Anna A Karsten Maria M MM Boisen Michelle M MM Elishaev Esther E Lucas Peter C PC Lee Adrian V AV Oesterreich Steffi S
NPJ breast cancer 20190627
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that requires novel therapies in the advanced setting. To study acquired resistance to endocrine therapy in ILC, we have recently performed RNA-Sequencing on long-term estrogen deprived cell lines and identified FGFR4 overexpression as a top druggable target. Here, we show that FGFR4 expression also increases dramatically in endocrine-treated distant metastases, with an average fold change of 4.8 relative to the paired ...[more]