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Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization.

ABSTRACT: Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs released by bone-related functional cells, and they participate in the regulation of cell mineralization. Here, we report bioinspired MVs embedded with black phosphorus (BP) and functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioinspired MVs to targeted cells, and the increasing concentration of inorganic phosphate originating from BP can facilitate cell biomineralization. The photothermal effect of the Apt-bioinspired MVs can also promote the biomineralization process by stimulating the upregulated expression of heat shock proteins and alkaline phosphatase. In addition, the Apt-bioinspired MVs display outstanding bone regeneration performance. Our strategy provides a method for designing bionic tools to study the mechanisms of biological processes and advance the development of medical engineering.

SUBMITTER: Wang Y

PROVIDER: S-EPMC6597708 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization.

Wang Yingqian Y Hu Xiaoxia X Zhang Lingling L Zhu Chunli C Wang Jie J Li Yingxue Y Wang Yulan Y Wang Can C Zhang Yufeng Y Yuan Quan Q

Nature communications 20190627 1

Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs released by bone-related functional cells, and they participate in the regulation of cell mineralization. Here, we report bioinspired MVs embedded with black phosphorus (BP) and functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioin ...[more]

PMID: 31249296

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Dataset Information

Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization.

Publications

Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization.

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