Ontology highlight
ABSTRACT:
SUBMITTER: Ramezani M
PROVIDER: S-EPMC6597712 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ramezani Meraj M Wilkes Marcus M MM Das Tapojyoti T Holowka David D Eliezer David D Baird Barbara B
NPJ Parkinson's disease 20190627
We characterized phenotypes in RBL-2H3 mast cells transfected with human alpha synuclein (a-syn) using stimulated exocytosis of recycling endosomes as a proxy for similar activities of synaptic vesicles in neurons. We found that low expression of a-syn inhibits stimulated exocytosis and that higher expression causes slight enhancement. NMR measurements of membrane interactions correlate with these functional effects: they are eliminated differentially by mutants that perturb helical structure in ...[more]