Unknown

Dataset Information

0

Implications of Immunotherapy in Hepatobiliary Tumors.


ABSTRACT: Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related death worldwide. Upon ineligibility for resection, liver transplantation, or locoregional therapies, sorafenib has been the only systemic treatment option of advanced HCC for more than a decade. Immunotherapy is an evolving HCC treatment option that has shown promise in treatment efficacy at an acceptable safety profile during several preceding phase I/II trials. Numerous clinical trials of immune checkpoint inhibitors (ICPIs) alone, in combination of two, or combined with other targeted or locoregional therapies are ongoing. Encouraging results of two-phase III trials testing pembrolizumab or nivolumab versus standard care therapy even resulted in Food and Drug Administration approval for second-line treatment of advanced HCC. ICPIs may open new avenues to the treatment of hepatobiliary tumors, alone or in combination.

SUBMITTER: Gottlieb A 

PROVIDER: S-EPMC6597927 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Implications of Immunotherapy in Hepatobiliary Tumors.

Gottlieb Aline A   Best Jan J   Canbay Ali A  

Visceral medicine 20190208 1


Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related death worldwide. Upon ineligibility for resection, liver transplantation, or locoregional therapies, sorafenib has been the only systemic treatment option of advanced HCC for more than a decade. Immunotherapy is an evolving HCC treatment option that has shown promise in treatment efficacy at an acceptable safety profile during several preceding phase I/II trials. Numerous clinical trials of immune checkpoint inhib  ...[more]

Similar Datasets

| S-EPMC8393650 | biostudies-literature
| S-EPMC9698563 | biostudies-literature
| S-EPMC4024136 | biostudies-literature
| S-EPMC7730788 | biostudies-literature
| S-EPMC7423557 | biostudies-literature
| S-EPMC5848044 | biostudies-literature
2014-03-14 | E-GEOD-53388 | biostudies-arrayexpress
| S-EPMC5669868 | biostudies-literature
| S-EPMC9179498 | biostudies-literature
| S-EPMC7061229 | biostudies-literature