Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.
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ABSTRACT:
SUBMITTER: Griffiths WJ
PROVIDER: S-EPMC6597949 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.
Griffiths William J WJ Abdel-Khalik Jonas J Yutuc Eylan E Roman Gustavo G Warner Margaret M Gustafsson Jan-Åke JÅ Wang Yuqin Y
Free radical biology & medicine 20181219
Using liquid chromatography - mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer's disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to ...[more]
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