Ontology highlight
ABSTRACT:
SUBMITTER: Elliott P
PROVIDER: S-EPMC6598200 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Elliott Paul P Posma Joram M JM Chan Queenie Q Garcia-Perez Isabel I Wijeyesekera Anisha A Bictash Magda M Ebbels Timothy M D TM Ueshima Hirotsugu H Zhao Liancheng L van Horn Linda L Daviglus Martha M Stamler Jeremiah J Holmes Elaine E Nicholson Jeremy K JK
Science translational medicine 20150429 285
Obesity is a major public health problem worldwide. We used 24-hour urinary metabolic profiling by proton ((1)H) nuclear magnetic resonance (NMR) spectroscopy and ion exchange chromatography to characterize the metabolic signatures of adiposity in the U.S. (n = 1880) and UK (n = 444) cohorts of the INTERMAP (International Study of Macro- and Micronutrients and Blood Pressure) epidemiologic study. Metabolic profiling of urine samples collected over two 24-hour time periods 3 weeks apart showed re ...[more]