Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring.
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ABSTRACT:
SUBMITTER: Fayomi AP
PROVIDER: S-EPMC6598202 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring.
Fayomi Adetunji P AP Peters Karen K Sukhwani Meena M Valli-Pulaski Hanna H Shetty Gunapala G Meistrich Marvin L ML Houser Lisa L Robertson Nicola N Roberts Victoria V Ramsey Cathy C Hanna Carol C Hennebold Jon D JD Dobrinski Ina I Orwig Kyle E KE
Science (New York, N.Y.) 20190301 6433
Testicular tissue cryopreservation is an experimental method to preserve the fertility of prepubertal patients before they initiate gonadotoxic therapies for cancer or other conditions. Here we provide the proof of principle that cryopreserved prepubertal testicular tissues can be autologously grafted under the back skin or scrotal skin of castrated pubertal rhesus macaques and matured to produce functional sperm. During the 8- to 12-month observation period, grafts grew and produced testosteron ...[more]
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