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Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.

ABSTRACT: PURPOSE:Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL. METHODS:Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoffs (VC ?=?10-40?cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were carried out in 10 healthy volunteers (1F/9M age 23-30 y). Myocardial blood flow (MBF) and temporal signal-to-noise (TSNR) were measured. RESULTS:VSASL sensitivity to perfusion decreased with increasing VC . At low VC (<5?cm/s), spurious labeling of myocardium occurs and overestimates MBF. MBF measured with FAIR (1.12?±?0.26?ml/g/min) and VASL (1.26?±?0.27?ml/g/min) at VC of 10?cm/s in Z were comparable (TOST with difference of 0.30?ml/g/min, P?=?0.049). TSNR was 2.8 times larger using FAIR (13.62?±?5.25) than in VSASL (4.87?±?1.58). VSASL was insensitive to perfusion in the Y direction. X and Z performed similarly with TSNR of 4.17?±?2.32 and 3.97?±?0.56, respectively. CONCLUSION:VSASL is a promising alternative to FAIR ASL in the heart and is well suited for scenarios when transit delays are long. Magn Reson Med 80:272-278, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Jao TR

PROVIDER: S-EPMC6598714 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.

Jao Terrence R TR Nayak Krishna S KS

Magnetic resonance in medicine 20171106 1

<h4>Purpose</h4>Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL.<h4>Methods</h4>Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoff ...[more]

PMID: 29106745

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Project description:PurposeVelocity-selective arterial spin labeling (VSASL) has been proposed for renal perfusion imaging to mitigate planning challenges and effects of arterial transit time (ATT) uncertainties. In VSASL, label generation may shift in the vascular tree as a function of cutoff velocity. Here, we investigate label dynamics and especially the ATT of renal VSASL and compared it with a spatially selective pulsed arterial spin labeling technique, flow alternating inversion recovery (FAIR).MethodsArterial spin labeling data were acquired in 7 subjects, using free-breathing dual VSASL and FAIR with five postlabeling delays: 400, 800, 1200, 2000, and 2600 ms. The VSASL measurements were acquired with cutoff velocities of 5, 10, and 15 cm/s, with anterior-posterior velocity-encoding direction. Cortical perfusion-weighted signal, temporal SNR, quantified renal blood flow, and arterial transit time were reported.ResultsIn contrast to FAIR, renal VSASL already showed fairly high signal at the earliest postlabeling delays, for all cutoff velocities. The highest VSASL signal and temporal SNR was obtained with a cutoff velocity of 10 cm/s at postlabeling delay = 800 ms, which was earlier than for FAIR at 1200 ms. Fitted ATT on VSASL was ≤ 0 ms, indicating ATT insensitivity, which was shorter than for FAIR (189 ± 79 ms, P < .05). Finally, the average cortical renal blood flow measured with cutoff velocities of 5 cm/s (398 ± 84 mL/min/100 g) and 10 cm/s (472 ± 160 mL/min/100 g) were similar to renal blood flow measured with FAIR (441 ± 84 mL/min/100 g) (P > .05) with good correlations on subject level.ConclusionVelocity-selective arterial spin labeling in the kidney reduces ATT sensitivity compared with the recommended pulsed arterial spin labeling method, as well as if cutoff velocity is increased to reduce spurious labeling due to motion. Thus, VSASL has potential as a method for time-efficient, single-time-point, free-breathing renal perfusion measurements, despite lower tSNR than FAIR.

Dataset Information

Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.

Publications

Demonstration of velocity selective myocardial arterial spin labeling perfusion imaging in humans.

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