Ontology highlight
ABSTRACT:
SUBMITTER: Jiang S
PROVIDER: S-EPMC6598906 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Jiang Shujuan S Huang Yujing Y Qi Ying Y He Rong R Liu Zhongyang Z Ma Yanping Y Guo Xin X Shao Yaozhong Y Sun Zhengrong Z Ruan Qiang Q
Virologica Sinica 20171031 5
Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. MicroRNAs (miRNAs), which function as post-transcriptional regulators, are utilized by human cytomegalovirus (HCMV) in its infection and pathogenesis. In the present study, the DNA replication inhibitor Geminin (GMNN) was identified to be a direct target of hcmv-miR-US5-1. Overexpression of hcmv-miR-US5-1 could block the accumulation of GMNN during HCMV infection, and the decrease of GMNN expres ...[more]