Ontology highlight
ABSTRACT:
SUBMITTER: Benz M
PROVIDER: S-EPMC6599004 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Benz Maximilian M Molla Mijanur R MR Böser Alexander A Rosenfeld Alisa A Levkin Pavel A PA
Nature communications 20190628 1
Drug development often relies on high-throughput cell-based screening of large compound libraries. However, the lack of miniaturized and parallelized methodologies in chemistry as well as strict separation and incompatibility of the synthesis of bioactive compounds from their biological screenings makes this process expensive and inefficient. Here, we demonstrate an on-chip platform that combines solution-based synthesis of compound libraries with high-throughput biological screenings (chemBIOS) ...[more]