The structure of a 15-stranded actin-like filament from Clostridium botulinum.
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ABSTRACT:
SUBMITTER: Koh F
PROVIDER: S-EPMC6599009 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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The structure of a 15-stranded actin-like filament from Clostridium botulinum.
Koh Fujiet F Narita Akihiro A Lee Lin Jie LJ Tanaka Kotaro K Tan Yong Zi YZ Dandey Venkata P VP Popp David D Robinson Robert C RC
Nature communications 20190628 1
Microfilaments (actin) and microtubules represent the extremes in eukaryotic cytoskeleton cross-sectional dimensions, raising the question of whether filament architectures are limited by protein fold. Here, we report the cryoelectron microscopy structure of a complex filament formed from 15 protofilaments of an actin-like protein. This actin-like ParM is encoded on the large pCBH Clostridium botulinum plasmid. In cross-section, the ~26 nm diameter filament comprises a central helical protofilam ...[more]
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