Ontology highlight
ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC6599043 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Xie Jingke J Ge Weikai W Li Nan N Liu Qishuai Q Chen Fangbing F Yang Xiaoyu X Huang Xingyun X Ouyang Zhen Z Zhang Quanjun Q Zhao Yu Y Liu Zhaoming Z Gou Shixue S Wu Han H Lai Chengdan C Fan Nana N Jin Qin Q Shi Hui H Liang Yanhui Y Lan Ting T Quan Longquan L Li Xiaoping X Wang Kepin K Lai Liangxue L
Nature communications 20190628 1
Cytosine base editors (CBEs) enable programmable C-to-T conversion without DNA double-stranded breaks and homology-directed repair in a variety of organisms, which exhibit great potential for agricultural and biomedical applications. However, all reported cases only involved C-to-T substitution at a single targeted genomic site. Whether C-to-T substitution is effective in multiple sites/loci has not been verified in large animals. Here, by using pigs, an important animal for agriculture and biom ...[more]