Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Ruiz A
PROVIDER: S-EPMC6599277 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Diaz-Ruiz Alberto A Di Francesco Andrea A Carboneau Bethany A BA Levan Sophia R SR Pearson Kevin J KJ Price Nathan L NL Ward Theresa M TM Bernier Michel M de Cabo Rafael R Mercken Evi M EM
The journals of gerontology. Series A, Biological sciences and medical sciences 20190101 2
Caloric restriction (CR) is the most potent nonpharmacological intervention known to both protect against carcinogenesis and delay aging in laboratory animals. There is a growing number of anticarcinogens and CR mimetics that activate NAD(P)H:quinone oxidoreductase 1 (NQO1). We have previously shown that NQO1, an antioxidant enzyme that acts as an energy sensor through modulation of intracellular redox and metabolic state, is upregulated by CR. Here, we used NQO1-knockout (KO) mice to investigat ...[more]