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Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.

ABSTRACT: BACKGROUND & AIMS:Lactation lowers blood glucose and triglycerides, and increases insulin sensitivity. We hypothesized that a longer duration of lactation would be associated with lower prevalence of non-alcoholic fatty liver disease (NAFLD), which is the leading cause of chronic liver disease in the United States. METHODS:Participants from the Coronary Artery Risk Development in Young Adults cohort study who delivered???1 child post-baseline (Y0: 1985-1986), and underwent CT quantification of hepatic steatosis 25?years following cohort entry (Y25: 2010-2011) were included (n?=?844). The duration of lactation was summed for all post-baseline births, and NAFLD at Y25 was assessed by central review of CT images and defined by liver attenuation???40 Hounsfield Units after exclusion of other causes of hepatic steatosis. Unadjusted and multivariable logistic regression analyses were performed using an a priori set of confounding variables; age, race, education, and baseline body mass index. RESULTS:Of 844 women who delivered after baseline (48% black, 52% white, mean age 49?years at Y25 exam), 32% reported lactation duration of 0 to 1?month, 25% reported >1 to 6?months, 43% reported more than 6?months, while 54 (6%) had NAFLD. Longer lactation duration was inversely associated with NAFLD in unadjusted logistic regression. For women who reported >6?months lactation compared to those reporting 0-1?month, the odds ratio for NAFLD was 0.48 (95% CI 0.25-0.94; p?=?0.03) and the association remained after adjustment for confounders (adjusted odds ratio 0.46; 95% CI 0.22-0.97; p?=?0.04). CONCLUSIONS:A longer duration of lactation, particularly greater than 6?months, is associated with lower odds of NAFLD in mid-life and may represent a modifiable risk factor for NAFLD. LAY SUMMARY:A longer duration of breastfeeding has been associated with multiple potential health benefits for the mother including reduction in heart disease, diabetes and certain cancers. In this study we found that breastfeeding for longer than 6?months was associated with a lower risk of non-alcoholic fatty liver disease in mid-life.

SUBMITTER: Ajmera VH

PROVIDER: S-EPMC6599460 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.

Ajmera Veeral H VH Terrault Norah A NA VanWagner Lisa B LB Sarkar Monika M Lewis Cora E CE Carr John J JJ Gunderson Erica P EP

Journal of hepatology 20181101 1

<h4>Background & aims</h4>Lactation lowers blood glucose and triglycerides, and increases insulin sensitivity. We hypothesized that a longer duration of lactation would be associated with lower prevalence of non-alcoholic fatty liver disease (NAFLD), which is the leading cause of chronic liver disease in the United States.<h4>Methods</h4>Participants from the Coronary Artery Risk Development in Young Adults cohort study who delivered ≥ 1 child post-baseline (Y0: 1985-1986), and underwent CT quan ...[more]

PMID: 30392752

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Project description:BackgroundNut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. However, the influence on the prevalence and severity of non-alcoholic fatty liver disease (NAFLD) has yet to be evaluated.Methods4655 subjects were included as part of a colorectal carcinoma screening program (SAKKOPI) between 07/2010 and 07/2019 and analyzed 2020. Patients were characterized using biochemical and metabolic parameters, as well as a detailed questionnaire on dietary habits. The diagnosis of NAFLD was established using abdominal ultrasound. Consumption of nuts was graded as: no consumption or <1 time/week, 1-6 times/week, 1 time/day and ≥2 times/day.ResultsMean age was 58.5±9.8years with a mean BMI of 26.5±4.7kg/m2. 2058 (44.2%) patients suffered from the metabolic syndrome, 2407 (51.6%) had arterial hypertension, 2287 (49.1%) showed prediabetes/diabetes, 1854 (39.4%) had dyslipidemia and 1984 patients (43.5%) were diagnosed with NAFLD. Prevalence of metabolic syndrome (1219 [48.7%] vs. 605 [40.2%] vs. 189 [37.4%] vs. 45 [31.7%], p<0.001) and NALFD (1184 [48.1%] vs. 594 [40.7%] vs. 158 [31.7%] vs. 48 [34.0%], p<0.001). On multivariable logistic regression analysis adjusting for potential confounders and dietary patterns, nut consumption ≥1time/day was inversely associated with NAFLD in the overall cohort (adjusted Odds ratio[aOR]: 0.719 [95%CI:0.558-0.926], p = 0.011). However, following subgroup analysis, this inverse association was only confirmed in male patients (aOR: 0.589 [95%CI: 0.411-0.844], p = 0.004) but not in females (aOR: 0.886 [95%CI: 0.616-1.275], p = 0.515). Moreover, patients who consumed nuts 1-6 times/week had a significantly lower prevalence of advanced fibrosis (Fib-4 score >2.67: aOR: 0.551 [95%CI: 0.338-0.898], p = 0.017; Forns-Index >6.9: aOR: 0.585 [95%CI: 0.402-0.850], p = 0.005).ConclusionsNut consumption might exert beneficial effects on the prevalence of NAFLD in males. The negative association with advanced fibrosis warrants further investigation.

Dataset Information

Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.

Publications

Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women.

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