Ontology highlight
ABSTRACT:
SUBMITTER: Rodon J
PROVIDER: S-EPMC6599610 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Rodon Jordi J Soria Jean-Charles JC Berger Raanan R Miller Wilson H WH Rubin Eitan E Kugel Aleksandra A Tsimberidou Apostolia A Saintigny Pierre P Ackerstein Aliza A Braña Irene I Loriot Yohann Y Afshar Mohammad M Miller Vincent V Wunder Fanny F Bresson Catherine C Martini Jean-François JF Raynaud Jacques J Mendelsohn John J Batist Gerald G Onn Amir A Tabernero Josep J Schilsky Richard L RL Lazar Vladimir V Lee J Jack JJ Kurzrock Razelle R
Nature medicine 20190422 5
Precision medicine focuses on DNA abnormalities, but not all tumors have tractable genomic alterations. The WINTHER trial ( NCT01856296 ) navigated patients to therapy on the basis of fresh biopsy-derived DNA sequencing (arm A; 236 gene panel) or RNA expression (arm B; comparing tumor to normal). The clinical management committee (investigators from five countries) recommended therapies, prioritizing genomic matches; physicians determined the therapy given. Matching scores were calculated post-h ...[more]