Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC6600216 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wu Chongchao C Cui Xiaofang X Huang Liyu L Shang Xueying X Wu Binghao B Wang Na N He Kunyan K Han Zeguang Z
International journal of molecular sciences 20190611 11
Insulin signaling is mediated by a highly integrated network that controls glucose metabolism, protein synthesis, cell growth, and differentiation. Our previous work indicates that the insulin receptor tyrosine kinase substrate (IRTKS), also known as BAI1-associated protein 2-like 1 (BAIAP2L1), is a novel regulator of insulin network, but the mechanism has not been fully studied. In this work we reveal that IRTKS co-localizes with Src homology (SH2) containing inositol polyphosphate 5-phosphatas ...[more]