Ontology highlight
ABSTRACT:
SUBMITTER: Mohos V
PROVIDER: S-EPMC6600370 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Mohos Violetta V Pánovics Attila A Fliszár-Nyúl Eszter E Schilli Gabriella G Hetényi Csaba C Mladěnka Přemysl P Needs Paul W PW Kroon Paul A PA Pethő Gábor G Poór Miklós M
International journal of molecular sciences 20190531 11
Quercetin is an abundant flavonoid in nature and is used in several dietary supplements. Although quercetin is extensively metabolized by human enzymes and the colonic microflora, we have only few data regarding the pharmacokinetic interactions of its metabolites. Therefore, we investigated the interaction of human and microbial metabolites of quercetin with the xanthine oxidase enzyme. Inhibitory effects of five conjugates and 23 microbial metabolites were examined with 6-mercaptopurine and xan ...[more]