Ontology highlight
ABSTRACT:
SUBMITTER: Fujiwara A
PROVIDER: S-EPMC6600409 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Fujiwara Atsushi A Hatayama Naoyuki N Matsuura Natsumi N Yokota Naoya N Fukushige Kaori K Yakura Tomiko T Tarumi Shintaro S Go Tetsuhiko T Hirai Shuichi S Naito Munekazu M Yokomise Hiroyasu H
International journal of molecular sciences 20190603 11
(1) Background: Heme oxygenase-1 (HO-1) degrades heme and generates carbon monoxide (CO), producing various anti-inflammatory, anti-oxidative, and anti-apoptotic effects. This study aimed to confirm the effects of CO on the ischemia-reperfusion injury (IRI) of donor lungs using a high-pressure gas (HPG) preservation method. (2) Methods: Donor rat and canine lungs were preserved in a chamber filled with CO (1.5 atm) and oxygen (O<sub>2</sub>; 2 atm) and were ventilated with either CO and O<sub>2< ...[more]