Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC6600440 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wu Chao C Chakrabarty Swapan S Jin Minghui M Liu Kaiyu K Xiao Yutao Y
International journal of molecular sciences 20190610 11
ATP-binding cassette (ABC) transporters, a large class of transmembrane proteins, are widely found in organisms and play an important role in the transport of xenobiotics. Insect ABC transporters are involved in insecticide detoxification and <i>Bacillus thuringiensis</i> (Bt) toxin perforation. The complete ABC transporter is composed of two hydrophobic transmembrane domains (TMDs) and two nucleotide binding domains (NBDs). Conformational changes that are needed for their action are mediated by ...[more]