Ontology highlight
ABSTRACT:
SUBMITTER: Myung J
PROVIDER: S-EPMC6600447 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Myung Jihwan J Wu Mei-Yi MY Lee Chun-Ya CY Rahim Amalia Ridla AR Truong Vuong Hung VH Wu Dean D Piggins Hugh David HD Wu Mai-Szu MS
International journal of molecular sciences 20190605 11
The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus ( ...[more]