Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Muniz R
PROVIDER: S-EPMC6600640 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20190528 11
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion channel, activated by low temperatures (<28 °C), pressure, and cooling compounds (menthol, icilin). Experimental evidences indicated a role of TRPM8 in cold thermal transduction, different life-threatening tumors, and other pathologies, including migraine, urinary tract dysfunction, dry eye disease, and obesity. Hence, the modulation of the TRPM8 channel could be essential in order to understand its i ...[more]