Ontology highlight
ABSTRACT:
SUBMITTER: Pekkanen-Mattila M
PROVIDER: S-EPMC6600740 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Pekkanen-Mattila Mari M Häkli Martta M Pölönen Risto-Pekka RP Mansikkala Tuomas T Junnila Anni A Talvitie Elina E Koivisto Janne T JT Kellomäki Minna M Aalto-Setälä Katriina K
Materials (Basel, Switzerland) 20190603 11
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to serve as a model for human cardiomyocytes. However, hiPSC-CMs are still considered immature. CMs differentiated from hiPSCs more resemble fetal than adult cardiomyocytes. Putative factors enhancing maturation include in vitro culture duration, culture surface topography, and mechanical, chemical, and electrical stimulation. Stem cell-derived cardiomyocytes are traditionally cultured on glass surfaces coa ...[more]