Ontology highlight
ABSTRACT:
SUBMITTER: Goossens C
PROVIDER: S-EPMC6600878 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Goossens Chloë C Goossens Chloë C Weckx Ruben R Derde Sarah S Dufour Thomas T Vander Perre Sarah S Pauwels Lies L Thiessen Steven E SE Van Veldhoven Paul P PP Van den Berghe Greet G Langouche Lies L
Critical care (London, England) 20190701 1
<h4>Background</h4>ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle wasting and weakness. Here, we hypothesized that this protection was due to increased lipid and ketone availability.<h4>Methods</h4>In a centrally catheterized, fluid-resuscitated, antibiotic-treated mouse model of prolonged sepsis, we compared markers of lipolysis and f ...[more]