Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC6601544 | biostudies-literature | 2019 May/Jun
REPOSITORIES: biostudies-literature
Chen Chen C Wakabayashi Tetsuya T Muraoka Masaru M Shu Feng F Wei Shan Chia C Chor Kun Chong C Tim Jang Ching C Soehano Ishin I Shimizu Yuichiro Y Igawa Tomoyuki T Nezu Jun-Ichi JI
mAbs 20190321 4
The complex molecular formats of recent therapeutic antibodies, including bispecific antibodies, antibody fragments, and other fusion proteins, makes the task of purifying the desired molecules in a limited number of purification steps more and more challenging. Manufacturing these complicated biologics can be substantially improved in the affinity capture stage if the simple bind-and-elute mode is accompanied by targeted removal of the impurities, such as mis-paired antibodies and oligomers or ...[more]