Ontology highlight
ABSTRACT:
SUBMITTER: Darowski D
PROVIDER: S-EPMC6601549 | biostudies-literature | 2019 May/Jun
REPOSITORIES: biostudies-literature
Darowski Diana D Kobold Sebastian S Jost Christian C Klein Christian C
mAbs 20190417 4
Chimeric antigen receptor (CAR)-engineered T cells have a proven efficacy for the treatment of refractory hematological B cell malignancies. While often accompanied by side effects, CAR-T technology is getting more mature and will become an important treatment option for various tumor indications. In this review, we summarize emerging approaches that aim to further evolve CAR-T cell therapy based on combinations of so-called universal or modular CAR-(modCAR-)T cells, and their respective adaptor ...[more]