Ontology highlight
ABSTRACT:
SUBMITTER: Kenner LR
PROVIDER: S-EPMC6601628 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kenner Lillian R LR Anand Aditya A AA Nguyen Henry C HC Myasnikov Alexander G AG Klose Carolin J CJ McGeever Lea A LA Tsai Jordan C JC Miller-Vedam Lakshmi E LE Walter Peter P Frost Adam A
Science (New York, N.Y.) 20190501 6439
The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a guanosine triphosphatase that becomes activated by eIF2B, a two-fold symmetric and heterodecameric complex that functions as eIF2's dedicated nucleotide exchange factor. Phosphorylation converts eIF2 from a substrate into an inhibitor of eIF2B. We report cryo-electron microscopy structures of eIF2 bound to eIF2B in the dephos ...[more]