Dataset Information

Emotional modulation of the pupil response in psychopathy.

ABSTRACT: Psychopathy is a form of personality disorder associated with a deficit in emotional processing. However, there is debate whether this deficit applies to all emotions or exists only for negative emotions. The pupil dilates rapidly in response to emotional stimuli, allowing a time-sensitive index of emotional processing. Across 3 experiments using (a) visual images of real-world scenes, (b) auditory sound clips, and (c) videos of dynamic facial expressions, we measured emotional modulation of the pupil response to both negative and positive stimuli. Participants were 82 male mentally disordered offenders. Psychopathy was measured using the Psychopathy Checklist-Revised to produce factor scores of interpersonal-affective traits (Factor 1) and lifestyle-antisocial traits (Factor 2). Participants with high Factor 1 scores showed reduced emotional modulation of the pupil response to negative images and angry faces but not to any of the positive stimuli. These effects only occurred shortly after the emotion was presented (<2,000 ms), suggesting delayed processing of negative affective stimuli in Factor 1 psychopathy. Factor 2 scores were not associated with any changes in pupil response. There were no effects of psychopathy on the pupil response to the affective sound clips. The results support a specific psychopathic deficit in the processing of negative stimuli related to the interpersonal-affective dimension of psychopathy. We argue that pupillometry is a powerful and noninvasive tool to investigate emotional processing in clinical populations. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

SUBMITTER: Burley DT

PROVIDER: S-EPMC6602524 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Emotional modulation of the pupil response in psychopathy.

Burley Daniel T DT Gray Nicola S NS Snowden Robert J RJ

Personality disorders 20181203 4

Psychopathy is a form of personality disorder associated with a deficit in emotional processing. However, there is debate whether this deficit applies to all emotions or exists only for negative emotions. The pupil dilates rapidly in response to emotional stimuli, allowing a time-sensitive index of emotional processing. Across 3 experiments using (a) visual images of real-world scenes, (b) auditory sound clips, and (c) videos of dynamic facial expressions, we measured emotional modulation of the ...[more]

PMID: 30507237

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Project description:BackgroundAutism spectrum disorder (ASD) is marked by repetitive thinking and high rates of depression. Understanding the extent to which repetitive negative thinking in ASD reflects autistic stereotypy versus general depressive thinking patterns (e.g., rumination) could help guide treatment research to improve emotional health in ASD. We compared associations between rumination, depressive symptoms, and pupil response to social-emotional material in adults with ASD and typically developing (TD) adults with and without depression.MethodsN = 53 verbally fluent young adults were recruited to three cohorts: ASD, n = 21; TD-depressed, n = 13; never-depressed TD-controls, n = 19. Participants completed Ruminative Response Scale and Beck Depression Inventory self-reports and a passive-viewing task employing emotionally-expressive faces, during which pupillary motility was assessed to quantify cognitive-affective load. Main and interactive effects of cohort, emotion condition, and time on pupil amplitude were tested via a linear mixed effects analysis of variance using restricted maximum likelihood estimation. Similar procedures were used to test for effects of rumination and depressive symptoms on pupil amplitude over time within ASD.ResultsResponsive pupil dilation in the ASD cohort tended to be significantly lower than TD-depressed initially but increased to comparable levels by trial end. When viewing sad faces, individuals with ASD who had higher depression scores resembled TD-depressed participants' faster, larger, and sustained pupil response. Within ASD, depressive symptoms uniquely predicted early pupil response to sad faces, while rumination and depression scores each independently predicted sustained pupil response.ConclusionsPeople with elevated depressive symptoms appear to have faster and greater increases in pupil-indexed neural activation following sad stimuli, regardless of ASD status, suggesting the utility of conceptualizing rumination as depression-like in treatment. Ruminative processes may increase more slowly in ASD, suggesting the potential utility of interventions that decrease reactions before they are uncontrollable. Findings also reinforce the importance of testing for effects of internalizing variables in broader ASD research.

Dataset Information

Emotional modulation of the pupil response in psychopathy.

Publications

Emotional modulation of the pupil response in psychopathy.

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